Finally, a Tangential Flow Filtration (TFF) system that monitors concentration during your UF/DF run. No longer are you dependent solely on mass inputs and off-line fixed-pathlength UV-Vis spectrophotometers. Now, you can measure what truly matters in real-time: your concentration.
With the power of the KrosFlo® KR2i Automated TFF System and the insights from the CTech™ FlowVPX® System, you can take control of your process.
In-Line integration of the FlowVPX instrument to UF/DF operations provides real-time protein concentration monitoring while allowing for feedback control.
generates 12 “QC-grade” concentration measurements in 1 minute (5 pathlengths in 5 seconds) with continuous data acquisition during the UF/DF process.
allows for concentration measurement from 0.1 mg/ml to 300 mg/ml to be tested without dilution
Variable Pathlength Technology (VPT) allows the system to adjust to the right pathlength range for accurate measurements regardless of the molecule.
Integrated software combines the power of the KR2i automation with the real-time insight from the FlowVPX System to give you the data you need and the control you’ve desired.
By leveraging in-line concentration data, you are not required to do upfront calculation or overcompensate for variability.
Providing you with key process in-sights allows you to better under-stand your process—reduce cycling time and minimizing batch risk.
Focus on the end goal by eliminating a common source of error seen with concentration factor (intermediate characteristic).
With in-line concentration data as the primary control factor for the UF/DF run, the process was able to reach target final concentration regardless of starting volume, crossflow rate, TMP, or retentate hold-up volume.
Variable pathlength technology is delivered through the FlowVPX System in real-time during your process. The CTech™ SoloVPE® System is the perfect compliment to the RPM System, allowing at-line or off-line analysis that provides the same accurate analysis of your product and process. A single technology platform that drives alignment across various steps and functions.
|Bioprocess Step||CTech™ FlowVPX® System in-line (g/l)||CTech™ SoloVPE® System off-line (g/l)|