CTech FlowVPX® System

In-Line VPT Solution for GMP Manufacturing

Take control of your process with the CTech FlowVPX® System. The in-line Slope Spectroscopy® method enables users to monitor and optimize critical process parameters and make real time decisions for enhanced biologic product consistency and quality. Eliminate off-line measurements, out-of-spec results, and costly and time-consuming deviation reports by incorporating the FlowVPX System as part of your process analytical technology (PAT) strategy. In-line concentration measurements using the slope-based method, increases the efficiency of your process and avoids costly dilution and background correction steps.

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Capable of making spectral and fixed-point measurements at wavelengths between 190 nm and 1100 nm using variable pathlength technology, the FlowVPX System is adaptable to a wide range of sample types and the highest concentrations found in the biopharmaceutical industry. It can support lab-scale flow lines of 3 mm, pilot-scale flow lines of 10 mm, and production-scale flow lines of 22 mm. These processes include UF/DF, chromatography, mixing, and fill finish.  

Directly incorporating the FlowVPX System into one or more locations of a process stream helps to reveal process characteristics previously hidden from commonly used online fixed pathlength sensors. The versatility of this robust inprocess technology is unparalleled, helping you expedite process development and manufacturing time.

Key Benefits

Increase process understanding in process development stage to accelerate product to market

Reduce cycling time and increase process efficiency (yield, throughput, resource utilization) by eliminating delays associated with off-line testing

Strengthen your process control with high quality and highly reproducible results

Minimize risk with continuous monitoring throughout the process

Product Features

SoloVPX

GMP grade

316L stainless steel body is designed to be fully enclosed to withstand the harshest GMP manufacturing environments. Passed IP65, C1D2, CE marking.

21 CFR Part 11 & Annex 11 Compliant Software

ViPER Anlytx software platform enables SecureVPT settings for 21 CFR Part 11 and Annex 11 compliance.

Removable and interchangeable flow cells

Modular component design allows for increased scalability from development to laboratory to production with three different removable Flow Cell options:

flow cell

3 mm Flow Cell volume: 0.6 mL

flow cell

10 mm Flow Cell volume: 9.0 mL

flow cell

22 mm Flow Cell volume: 46.0 mL

Process connectivity via barb, Luer, and compression fittings (included).

Connectivity/System Integration

Designed with three digital input channels, three digital output channels, and two analog output channels to allow for seamless integration.

Robust and Automated Zeroing

Ensures accurate zeroing and prevents window breakage.

Linear Range-Finder Technology

The FlowVPX System automatically identifies the linear region of the section data sets to verify the compliance with Beer-Lambert law.

Education/Support

On-site installation and training included with System purchase.

Product Details

FlowVPE and FlowVPX

Product Feature Flow VPE Product Image FlowVPE View Product flowvpx_productv2 FlowVPX View Product
Data Collection At-line process analytics In-line process monitoring
Inline UV-Measurement
System Suitability Testing Capability
Minimum 5-Second Cycle Acquisition Time
CE System Certification
ViPER Software Compatibility
21 CFR Part 11 Compliance
Analog I/O
Digital I/O
Automated Zeroing
Smart Cell Operation
Process Status Indicators
C1D2 Rating
IP Rating N/A IP65
Concentration Range 0.1–250 mg/mL 0.1–300 mg/mL
Flow Cell Size Compatibility Up to 22 mm Increase scalability
Minimum Pathlength Step Size 5 µm 1 µm
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